The National Institutes of Health (NIH) reminds applicants that any research involving activities outside the U.S. or collaborations with international partners must be clearly indicated in the application. This includes identifying foreign components in the SF-424 R&R Other Project Information Form and attaching a “Foreign Justification” in Field 12 if applicable. A foreign component is defined as a significant project element conducted outside the U.S., even if not funded by NIH. Additional details may be required based on project specifics, such as human subjects or data sharing. Any changes to foreign components post-award require prior NIH approval. Read the full notice.