The Patient-Centered Outcomes Research Institute (PCORI) supports patient-centered comparative clinical effectiveness research (CER) designed to help patients, caregivers, and clinicians make more informed health care decisions. PCORI’s current funding opportunities emphasize the implementation, dissemination, and advancement of evidence-based interventions that improve health outcomes and address pressing public health challenges.
Open Solicitations:
Implementation of Findings from PCORI’s Research Investments supports implementation projects that promote the uptake of findings from PCORI-funded patient-centered CER in real-world settings. Priority evidence areas for Cycle 3 2026 include obsessive-compulsive disorder in youth, pediatric hospital admissions, early palliative care for advanced cancer, and caries prevention in children. For more information, visit PCORI Implementation of Findings from PCORI’s Research Investments.
Deadline: September 8, 2026 | Amount: Up to $1.8 million
Substance Use PCORI Funding Announcement — Cycle 3 2026 seeks patient-centered CER projects focused on substance use/misuse and substance use disorders, particularly among populations experiencing higher burden or reduced access to effective care. Areas of emphasis include overdose prevention, nicotine and tobacco reduction, prevention and treatment strategies, and interventions addressing the intersection of poor sleep and substance misuse. Additional details are available at PCORI Substance Use Funding Announcement — Cycle 3 2026.
Deadline: September 8, 2026 | Amount: Up to $12 million
Limited Competition PCORI Funding Announcement: Implementation Awards aims to move evidence from PCORI-funded CER into broader real-world practice through implementation, dissemination, and implementation planning projects. Eligible applicants include recipients of qualifying PCORI-funded CER awards seeking to expand the practical uptake and impact of their research findings. Funding levels include up to $1.8 million in direct costs for implementation projects, up to $300,000 for dissemination projects, and up to $200,000 for implementation planning projects. Learn more at PCORI Limited Competition Implementation Awards — Cycle 3 2026.
Deadline: September 8, 2026 | Amount: Varies