The Patient-Centered Outcomes Research Institute (PCORI) is accepting Letters of Intent for its Phased Large Awards for Comparative Effectiveness Research (PLACER) funding opportunity, which supports large-scale, patient-centered comparative effectiveness research addressing critical evidence gaps in healthcare decision-making. Projects must compare two or more widely used interventions with established evidence of efficacy through individual- or cluster-randomized controlled trials and focus on clinically meaningful outcomes important to patients and other healthcare stakeholders. Awards provide up to $2 million in direct costs for an 18-month feasibility phase and up to $20 million for a five-year full-scale phase, with combined direct costs of up to $22 million; applications requesting less than $12 million will not be considered responsive. Eligible applicants include universities, nonprofit and for-profit research organizations, and other qualified research entities; individuals may not apply. Letters of Intent are due January 6, 2027. Visit the PCORI PLACER funding announcement for complete requirements and application information.
LOI Deadline: January 6, 2027 | Amount: Varies